Cardiovascular Disease

Belanger AJ, Luo Z, Vincent KA, Akita GY, Cheng SH, Gregory RJ, Jiang C. 2007. Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor. Biochem Biophys Res Commun 364:567-572.

Rajagopalan S, Olin J, Deitcher S, Pieczek A, Laird J, Grossman PM, Goldman CK, McEllin K, Kelly R, Chronos N. 2007. Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience. Circulation 115:1234-1243.

Vincent KA, Jiang C, Boltje I, Kelly RA. 2007. Gene therapy progress and prospects: Therapeutic angiogenesis for ischemic cardiovascular disease. Gene Ther 14:781-789.

Luo Y, Jiang C, Belanger A, Akita G, Wadsworth S, Gregory R, Vincent K. 2006. A constitutively active HIF-1{alpha}/VP16 hybrid factor activates expression of the human B-Type natriuretic peptide gene. Mol Pharmacol.

Zhang M, Michael LH, Grosjean SA, Kelly RA, Carroll MC, Entman ML. 2006. The role of natural IgM in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 41:62-67.

Date T, Mochizuki S, Belanger AJ, Yamakawa M, Luo Z, Vincent KA, Cheng SH, Gregory RJ, Jiang C. 2005. Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. Am J Physiol Cell Physiol 288:C314-320.

Donovan JM, Von Bergmann K, Setchell KD, Isaacsohn J, Pappu AS, Illingworth DR, Olson T, Burke SK. 2005. Effects of colesevelam HC1 on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Dig Dis Sci 50:1232-1238.

Frantz S, Bauersachs J, Kelly RA. 2005. Innate immunity and the heart. Curr Pharm Des 11:1279-1290.

Frantz S, Vincent KA, Feron O, Kelly RA. 2005. Innate immunity and angiogenesis. Circ Res 96:15-26.

Heinl-Green A, Radke PW, Munkonge FM, Frass O, Zhu J, Vincent K, Geddes DM, Alton EW. 2005. The efficacy of a 'master switch gene' HIF-1alpha in a porcine model of chronic myocardial ischaemia. Eur Heart J 26:1327-1332.

Luo Z, Akita GY, Date T, Treleaven C, Vincent KA, Woodcock D, Cheng SH, Gregory RJ, Jiang C. 2005. Adenovirus-mediated expression of beta-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs. Circulation 111:1679-1684.

Jiang C, Yang Y-F, Cheng SH. 2004. Fas ligand gene therapy for vascular intimal hyperplasia. Curr Gene Ther 4:33-39.

Luo Z, Palasis M, Yamakawa M, Liu LX, Vincent KA, Trudell L, Akita GA, Koch WJ, Cheng SH, Gregory RJ, Jiang C. 2004. Catheter-mediated delivery of adenoviral vectors expressing beta-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries. J Gene Med 6:1061-1068.

Marquis JK, Dagher R, Jones M. 2004. Dietary administration of colesevelam hydrochloride does not affect fertility or reproductive performance in rats. Int J Toxicol 23:357-367.

Moore JW, Binder GA, Berry R. 2004. Prenatal diagnosis of aneuploidy and deletion 22q11.2 in fetuses with ultrasound detection of cardiac defects. Am J Obstet Gynecol 191:2068-2073.

Oyama J-i, Blais CJ, Liu X, Pu M, Kobzik L, Kelly RA, Bourcier T. 2004.Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109:784-789.

Date T, Luo Z, Yamakawa M, Belanger AJ, Scaria A, Cheng SH, Gregory RJ, Mochizuki S, Jiang C. 2003. Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats. Hum Gene Ther 14:947-957.

Date T, Mochizuki S, Belanger AJ, Yamakawa M, Luo Z, Vincent KA, Cheng SH, Gregory RJ, Jiang C. 2003. Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury. J Mol Cell Cardiol 35:811-821.

Lipshultz SE, Sleeper LA, Towbin JA, Lowe AM, Orav EJ, Cox GF, Lurie PR, McCoy KL, McDonald MA, Messere JE, Colan SD. 2003. The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med 348:1703-1705.

Nelson BC, Pfeiffer CM, Sniegoski LT, Satterfield MB. 2003. Development and evaluation of an isotope dilution LC/MS method for the determination of total homocysteine in human plasma. Anal Chem 75:775-784.

Stewart JD, Masi TL, Cumming AE, Molnar GM, Wentworth BM, Sampath K, McPherson JM, Yaeger PC. 2003. Characterization of proliferating human skeletal muscle-derived cells in vitro: differential modulation of myoblast markers by TGF-beta2. J Cell Physiol 196:70-78.

Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY, Kuriyama T, Cheng SH, Gregory RJ, Jiang C. 2003. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 93:664-673.

Belanger AJ, Lu H, Date T, Liu LX, Vincent KA, Akita GY, Cheng SH, Gregory RJ, Jiang C. 2002. Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha. J Mol Cell Cardiol 34:765-774.

Chertow GM, Burke SK, Raggi P. 2002. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 62:245-252.

Date T, Belanger AJ, Mochizuki S, Sullivan JA, Liu LX, Scaria A, Cheng SH, Gregory RJ, Jiang C. 2002. Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity. Cardiovasc Res 55:309-319.

Donovan JM, Kisicki JC, Stiles MR, Tracewell WG, Burke SK. 2002. Effect of colesevelam on lovastatin pharmacokinetics. Ann Pharmacother 36:392-397.

Feron O, Kelly RA. 2002. Gaining respectability: Membrane-delimited, caveolar-restricted activation of ion channels. Circ Res 90:369-370.

Jiang C, Lu H, Vincent KA, Shankara S, Belanger AJ, Cheng SH, Akita GY, Kelly RA, Goldberg MA, Gregory RJ. 2002. Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha. Physiol Genomics 8:23-32.

Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, Chertow GM. 2002. Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39:695-701.

Liu LX, Lu H, Luo Y, Date T, Belanger AJ, Vincent KA, Akita GY, Goldberg M, Cheng SH, Gregory RJ, Jiang C. 2002. Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1. Biochem Biophys Res Commun 291:908-914.

Oyama J-I, Frantz S, Blaid CJ, Kelly RA, Bourcier T, Jogdutt B. 2002. Nitric oxide, cell death, and heart failure. Heart Fail Rev 7:327-334.

Vincent KA, Feron O, Kelly RA. 2002. Harnessing the response to tissue hypoxia: HIF-1 alpha and therapeutic angiogenesis. Trends Cardiovasc Med 12:362-367.

Belanger AJ, Scaria A, Lu H, Sullivan JA, Cheng SH, Gregory RJ, Jiang C. 2001. Fas ligand/Fas-mediated apoptosis in human coronary artery smooth muscle cells: therapeutic implications of fratricidal mode of action. Cardiovasc Res 51:749-761.

Booker ML. 2001. S-8921 (Shionogi). Curr Opin Investig Drugs 2:393-395.

Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. 2001. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev 15:839-844.

Davidson MH, Toth P, Weiss S, McKenney J, Hunninghake D, Isaacsohn J, Donovan JM, Burke SK. 2001. Low-dose combination therapy with colesevelam hydrochloride and lovastatin effectively decreases low-density lipoprotein cholesterol in patients with primary hypercholesterolemia. Clin Cardiol 24:467-474.

Hunninghake D, Insull W, Jr., Toth P, Davidson D, Donovan JM, Burke SK. 2001. Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively. Atherosclerosis 158:407-416.

Knapp HH, Schrott H, Ma P, Knopp R, Chin B, Gaziano JM, Donovan JM, Burke SK, Davidson MH. 2001. Efficacy and safety of combination simvastatin and colesevelam in patients with primary hypercholesterolemia. Am J Med 110:352-360.

Luo Z, Garron T, Palasis M, Lu H, Belanger AJ, Scaria A, Vincent KA, Date T, Akita GY, Cheng SH, Barry J, Gregory RJ, Jiang C. 2001. Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35. Hum Gene Ther 12:2191-2202.