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2005 Annual Report
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TABLE OF CONTENTS
25 Years of Inspiration
Financial Highlights
Letter to Shareholders
Commitment Drives Growth
Bringing Myozyme to Market
Expanding Our Renal Franchise
Future Growth Drivers
A Strong Global Infrastructure
2005: The Year in Review
Genetic Diseases
Renal Disease
Orthopaedics
Oncology
Transplant and Immune Diseases
Genetics and Diagnostics
A Portfolio for the Future
Product Development Pipeline
Our Social Responsibility
Preparing for the Future
2005 Financial Highlights

  • Genzyme's revenue in 2005 increased 24 percent over 2004, exceeding $2.7 billion. Revenue gains were spread across our diversified business units. Overall, our strategy of diversification has resulted in a 5-year compound annual revenue growth rate of 29 percent.
  • We capitalized on the interconnections among our strategic acquisitions and our existing businesses, achieving successful integrations while sustaining top- and bottom-line growth. We made acquisitions from late 2004 through 2005 in areas including oncology, cancer diagnostics, orthopaedics, and renal disease.
  • Reaping the benefit of significant investments made in our pipeline and infrastructure over the past several years, we ended 2005 with a record number of both late-stage and early-stage clinical programs and opened new and expanded manufacturing facilities to support the development and commercialization of these product candidates.

2005 Financial Hightlights

* Represents the operations and financial position of Genzyme General Division from January 1, 2000 through June 30, 2003 and the operations of Genzyme Corporation from July 1, 2003 through December 31, 2005.
** Reflects 2-for-1 stock split of Genzyme Stock in June 2001. Based on net income per share allocated to Genzyme Stock.