Our Bulk Hyaluronan

Hyaluronan, known also as hyaluronic acid, is a naturally occurring glycosaminoglycan. It is a major constituent of the extracellular matrix of connective tissue present in almost all vertebrates, and can be found at high concentrations in the umbilical cord, the aqueous and vitreous humor of the eye and synovial joint fluid; it is also found in some strains of bacteria and in chicken combs.

In its natural form, hyaluronan typically exists as a sodium salt (sodium hyaluronate), which can form a highly viscous fluid with exceptional lubricating qualities. It plays an important role in a number of physiological functions including, cell protection and lubrication, maintenance of the structural integrity of tissues, transport of molecules, migration of cells and fluid retention and regulation.

It's biocompatible. It's bioabsorbable.

Its applicability for therapeutic products is far-reaching; the safety and clinical utility of hyaluronan in a variety of therapeutic areas has already been established. Existing and potential applications for hyaluronan include:

Ophthalmology Tissue augmentation Wound healing Viscosupplementation Bone regeneration

Surface coatings Moisturizing agents Adhesion prevention Cell preservation Drug delivery

As a worldwide leader in the manufacture of sterile and medical-grade hyaluronan, Genzyme utilizes a manufacturing process with propriety fermentation and purification technologies that yield a high-purity, high quality product. Process development and commercial-scale production take place in our dedicated facility in Massachusetts, in accordance with current Good Manufacturing Practice (cGMP) requirements. Genzyme Biosurgery’s standard product line is comprised of sterile and medical-grade hyaluronan; manufactured using non-animal derived components, it meets EP specifications. It is available in a broad range of molecular weights to meet the diverse needs of our customers. In addition, we are available to discuss customized HA.

Hylumed^® (sodium hyaluronate) Product Line Attributes

Fermentation production process:	Proprietary process.
Broad product range:	Hylumed Sterile: molecular weight range from 1.8–4.0 million.* Hylumed Medical: molecular weight range from 0.5–1.5 million.*
Regulatory support:	Genzyme provides customers with access to our Master Files, as well as worldwide support from our regulatory staff.
Custom HA:	Genzyme's R&D team is available to develop customized HA according to individual customer requirements, including molecular weights less than 10,000.*

*Molecular weight range as determined by light scattering.

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